2024-03-29T05:39:32Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/1257042024-02-08T10:45:32Zcom_10234_8033com_10234_9col_10234_8636
Repositori UJI
author
Alemany, Silvia
author
Arias, Barbara
author
Fatjó-Vilas, Mar
author
Villa Martín, Elena
author
Moya-Higueras, Jorge
author
Ibáñez, Manuel I
author
Ortet, Generós
author
Gastó, Cristóbal
author
Fañanás Saura, Lourdes
2015-07-01T11:02:39Z
2015-07-01T11:02:39Z
2014-01
ALEMANY, S...[et al.]. Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes. Acta Psychiatrica Scandinavica, v. 129, issue 1 (January 2014), pp. 54-62
http://hdl.handle.net/10234/125704
http://dx.doi.org/10.1111/acps.12108
OBJECTIVE:
To test whether the association between childhood abuse, cannabis use and psychotic experiences (PEs) was moderated by the COMT (catechol-O-methyltransferase) gene.
METHOD:
Psychotic experiences (PEs), childhood abuse, cannabis use and COMT Val158Met genotypes were assessed in 533 individuals from the general population. Data were analysed hierarchically by means of multiple linear regression models.
RESULTS:
Childhood abuse showed a significant main effect on both positive (β = 0.09; SE = 0.04; P = 0.047) and negative PEs (β = 0.11; SE = 0.05; P = 0.038). A significant three-way interaction effect was found among childhood abuse, cannabis use and the COMT gene on positive PEs (β = -0.30; SE = 0.11; P = 0.006). This result suggests that COMT genotypes and cannabis use only influenced PE scores among individuals exposed to childhood abuse. Furthermore, exposure to childhood abuse and cannabis use increased PE scores in Val carriers. However, in individuals exposed to childhood abuse but who did not use cannabis, PEs increased as a function of the Met allele copies of the COMT gene.
CONCLUSION:
Cannabis use after exposure to childhood abuse may have opposite effects on the risk of PEs, depending on the COMT genotypes providing evidence for a qualitative interaction. Val carriers exposed to childhood abuse are vulnerable to the psychosis-inducing effects of cannabis.
eng
Psychoses
Trauma
Cannabis
Genetics
Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes
info:eu-repo/semantics/article
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