2024-03-29T13:39:07Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/1221652022-12-14T12:16:45Zcom_10234_36080com_10234_9col_10234_36082
Repositori UJI
author
Martínez-Ricós, Joana
author
Agustín-Pavón, Carmen
author
Lanuza, Enrique
author
Martinez-Garcia, Fernando
2015-05-29T09:20:23Z
2015-05-29T09:20:23Z
2008-05
0306-4522
http://hdl.handle.net/10234/122165
http://dx.doi.org/10.1016/j.neuroscience.2008.02.002
Although it is generally accepted that rodents' sociosexual behavior relies mainly on chemosignals, the specific roles played by the vomeronasal and olfactory systems in detecting these signals are presently unclear. This work reports the results of three experiments aimed at clarifying the role of the vomeronasal system on gender recognition and intersexual attraction, by analyzing the effects of lesions of the accessory olfactory bulbs (AOB) in chemically naïve female mice. The first experiment demonstrates that lesions of the AOB abolish the preference that females show for male-soiled bedding in tests in which the females can contact the bedding, thus having access to both volatile and involatile male chemosignals. The second experiment shows that airborne male-derived chemosignals are not attractive to intact, chemically naïve females but tend to be preferentially explored by females whose AOB has been lesioned. However, repeated exposure to male-soiled bedding has opposite effects in sham-operated and AOB-lesioned female mice. Whereas after this experience sham-operated females show an (acquired) attraction toward male airborne chemosignals, in AOB-lesioned females the same experience makes male-derived volatiles aversive. Finally, in the third experiment we have confirmed that our AOB-lesioned females are able to detect urine-borne male odorants, as well as to discriminate them from the synthetic terpene geraniol. These findings strongly suggest that in mice, the involatile male sexual pheromone that is intrinsically attractive is detected by the vomeronasal system of the females. In addition, the repeated experience of females with male-soiled bedding would probably allow the association of this pheromone, acting as unconditioned stimulus, with olfactory stimuli (odorants) that therefore would become conditioned attractors to the females.
eng
© 2008 IBRO. Published by Elsevier Ltd. All rights reserved
olfactory system
pheromones
reward
emotional learning
sexual behavior
Role of the vomeronasal system in intersexual attraction in female mice
info:eu-repo/semantics/article
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