2024-03-29T04:54:58Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/891102021-06-10T17:50:27Zcom_10234_36080com_10234_9col_10234_36082
00925njm 22002777a 4500
dc
Herrero Ezquerro, María Trinidad
author
Blanco, Lisette
author
Yuste Jiménez, José Enrique
author
Carrillo de Sauvage, María Ángeles
author
Gómez, Aurora
author
Fernández Villalba, Emiliano
author
Avilés Olmos, Iciar
author
Limousin, Patricia
author
Zrinzo, Ludvic
author
2013
Deep brain stimulation (DBS) has become the standard surgical procedure for advanced Parkinson’s disease (PD). Recently, the pedunculopontine tegmental nucleus (PPN) has emerged as a potential target for DBS in patients whose quality of life is compromised by freezing of gait and falls. To date, only a few groups have published their long-term clinical experience with PPN stimulation. Bearing in mind that the Barrington (Bar) nucleus and some adjacent nuclei (also known as the micturition centre) are close to the PPN and may be affected by DBS, the aim of the present study was to review the anatomical location of this structure in human and other species. To this end, the Bar nucleus area was analysed in mouse, monkey and human tissues, paying particular attention to the anatomical position in humans, where it has been largely overlooked. Results confirm that anatomical location renders the Bar nucleus susceptible to influence by the PPN DBS lead or to diffusion of electrical current. This may have an undesirable impact on the quality of life of patients.
0306-4522
1873-7544
http://hdl.handle.net/10234/89110
http://dx.doi.org/10.1016/j.neuroscience.2013.05.047
Barrington nucleus
pedunculopontine nucleus
locus coeruleus
laterodorsal tegmental nucleus
micturition centre
Critical evaluation of the anatomical location of the Barrington nucleus: relevance for deep brain stimulation surgery of pedunculopontine tegmental nucleus