2024-03-29T14:10:31Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/857892024-01-29T07:28:09Zcom_10234_8033com_10234_9col_10234_8636
00925njm 22002777a 4500
dc
Costumero, Víctor
author
Barrós-Loscertales, Alfonso
author
Bustamante, Juan Carlos
author
Ventura Campos, Mercedes
author
Fuentes-Claramonte, Paola
author
Avila, Cesar
author
2013
Reward sensitivity, or the tendency to engage in motivated approach behavior in the presence of rewarding stimuli, may be a contributory factor for vulnerability to disinhibitory behaviors. Although evidence exists for a reward sensitivity-related increased response in reward brain areas (i.e. nucleus accumbens or midbrain) during the processing of reward cues, it is unknown how this trait modulates brain connectivity, specifically the crucial coupling between the nucleus accumbens, the midbrain, and other reward-related brain areas, including the medial orbitofrontal cortex and the amygdala. Here, we analysed the relationship between effective connectivity and personality in response to anticipatory reward cues. Forty-four males performed an adaptation of the Monetary Incentive Delay Task and completed the Sensitivity to Reward scale. The results showed the modulation of reward sensitivity on both activity and functional connectivity (psychophysiological interaction) during the processing of incentive cues. Sensitivity to reward scores related to stronger activation in the nucleus accumbens and midbrain during the processing of reward cues. Psychophysiological interaction analyses revealed that midbrain-medial orbitofrontal cortex connectivity was negatively correlated with sensitivity to reward scores for high as compared with low incentive cues. Also, nucleus accumbens-amygdala connectivity correlated negatively with sensitivity to reward scores during reward anticipation. Our results suggest that high reward sensitivity-related activation in reward brain areas may result from associated modulatory effects of other brain regions within the reward circuitry.
Eur J Neurosci. 2013 Aug;38(3):2399-407
1359-432X
1464-0643
http://hdl.handle.net/10234/85789
http://dx.doi.org/10.1111/ejn.12234
Dopamine
fMRI
Nucleus accumbens
Orbitofrontal cortex
Personality
Reward sensitivity modulates connectivity among reward brain areas during processing of anticipatory reward cues