2024-03-29T01:36:12Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/624932022-10-19T07:09:09Zcom_10234_2508com_10234_9col_10234_6999
00925njm 22002777a 4500
dc
MartÃ-Centelles, Vicente
author
Burguete, M. Isabel
author
Luis, Santiago V.
author
2012
Several kinetic models for the macrocyclization of a
C
2
pseudopeptide with a dihalide through a
S
N
2
reaction have been developed. These models not only focus on the kinetic analysis of the main macrocyclization reaction, but also consider the
competitive oligomerization/polymerization processes yielding undesired oligomeric/polymeric byproducts. The effect of anions has also been included in the kinetic models, as they can act as catalytic templates in the transition state reducing and stabilizing the transition state. The corresponding differential equation systems for each kinetic model can be solved numerically. Through a comprehensive analysis of these results, it is possible to obtain a better understanding of the different parameters that are involved in the macrocyclization reaction mechanism and to develop strategies for the optimization of the desired processes.
http://hdl.handle.net/10234/62493
http://dx.doi.org/10.1100/2012/748251
Kinetic analysis
Transition state
Macrocyclization
Kinetic analysis for macrocyclizations involving anionic template at the transition state