2024-03-29T11:25:09Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/494742023-09-26T12:49:50Zcom_10234_7053com_10234_9col_10234_8639
00925njm 22002777a 4500
dc
Sáez, José A.
author
Escuder, Beatriu
author
Miravet, Juan
author
2010
For the first time the combination of self-immolative spacers and supramolecular hydrogels has been tested in enzyme triggered drug release. Low-molecular weight drug-gelator conjugates have been prepared, which contain a gel forming lysine moiety linked to model drugs (benzylamine and phenethylamine) through a self-immolating spacer (p-aminobenzyloxycarbonyl). In the presence of trypsin the amide linkage between the gelator moiety and the spacer is hydrolyzed leading to the release of the model drug. This approach provides with distinct advantages, such as sustained release or versatility associated to the use of supramolecular hydrogels and self-immolative spacers, respectively. © 2010 Elsevier Ltd. All rights reserved.
Tetrahedron, 66, 14, p. 2614-2618
404020
http://hdl.handle.net/10234/49474
http://dx.doi.org/10.1016/j.tet.2010.02.033
Drug delivery
Enzyme catalysis
Prodrugs
Self-assembly
Self-immolation
Supramolecular hydrogels
Supramolecular hydrogels for enzymatically triggered self-immolative drug delivery