2024-03-29T05:54:49Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/1747582024-01-25T11:42:19Zcom_10234_8033com_10234_9col_10234_8636
00925njm 22002777a 4500
dc
Correa, Merce
author
Acquas, Elio
author
Salamone, John
author
2014-07-22
As with many events in the history of science, the development
of the hypothesis that acetaldehyde is a plausible psychoactive
substance with specific central effects (not related to its toxic-
ity) has not been either incremental or progressive. Rather, it has
evolved through a process of fits and starts. Initial clinical obser-
vations suggesting that accumulation of acetaldehyde could be
used as a therapy for alcoholism did not lead to a highly effective
treatment, and in fact, it was noted early on that small amounts
of ethanol consumed under these conditions (i.e., blockade of
aldehyde dehydrogenase) could be perceived as being even more
pleasurable (
Chevens, 1953
). Although some laboratory data in
animals appeared at that time (
Carpenter and Macleod, 1952), it
took a decade for the pre-clinical studies to focus on the poten-
tial importance of acetaldehyde. Since Myers proposed in the late
60’s that acetaldehyde could be a mediator of some of the effects
of ethanol (
Myers and Veale, 1969), advances in this field have
gone through a push-pull process.
CORREA SANZ, Mercè; ACQUAS, Elio; SALAMONE, John D. (2014). The renaissance of acetaldehyde as a psychoactive compound: decades in the making. Frontiers in Behavioral Neuroscience, v. 8
http://hdl.handle.net/10234/174758
https://doi.org/10.3389/fnbeh.2014.00249
Ethanol
Catalase
Acetate
Dopamine
Salsolinol
Opioids
Addiction
Drug abuse
The renaissance of acetaldehyde as a psychoactive compound: decades in the making