2024-03-29T12:03:22Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/1649992024-03-13T12:55:56Zcom_10234_2508com_10234_9com_10234_36080col_10234_6999col_10234_36082
00925njm 22002777a 4500
dc
Sánchez-Sarasúa, Sandra
author
Moustafa, S.
author
García Avilés, Álvaro
author
López Climent, María Fernanda
author
Gomez-Cadenas, Aurelio
author
Olucha-Bordonau, Francisco E
author
Sánchez-Pérez, Ana María
author
2016-10
Background
Western diet and lifestyle are associated with overweight, obesity, and type 2 diabetes, which, in turn, are correlated with neuroinflammation processes. Exercise and a healthy diet are important in the prevention of these disorders. However, molecules inhibiting neuroinflammation might also be efficacious in the prevention and/or treatment of neurological disorders of inflammatory etiology. The abscisic acid (ABA) is a phytohormone involved in hydric-stress responses. This compound is not only found in plants but also in other organisms, including mammals. In rodents, ABA can play a beneficial role in the regulation of peripheral immune response and insulin action. Thus, we hypothesized that chronic ABA administration might exert a protective effect in a model of neuroinflammation induced by high-fat diet (HFD).
Methods
Male Wistar rats were fed with standard diet or HFD with or without ABA in the drinking water for 12 weeks. Glucose tolerance test and behavioral paradigms were performed to evaluate the peripheral and central effects of treatments. One-Way ANOVA was performed analyzed statistical differences between groups.
Results
The HFD induced insulin resistance peripherally and increased the levels of proinflammatory markers in in the brain. We observed that ABA restored glucose tolerance in HFD-fed rats, as expected. In addition, chronic ABA treatment rescued cognitive performance in these animals, while not affecting control diet fed animals. Moreover, it counteracted the changes induced by HFD in the hypothalamus; microglia activations and TNFα mRNA levels.
Conclusion
These results suggest that ABA might become a new therapeutic molecule improving the neuroinflammatory status and insulin resistance.
SÁNCHEZ-SARASÚA, Sandra, et al. The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation. Nutrition & Metabolism, 2016, vol. 13, no 1, p. 73.
http://hdl.handle.net/10234/164999
http://dx.doi.org/10.1186/s12986-016-0137-3
obesity
working memory
microglia
phytohormones
The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation