2024-03-29T11:43:51Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/1622342019-11-18T12:50:54Zcom_10234_71324com_10234_158176col_10234_97314
00925njm 22002777a 4500
dc
Sebastián Fuertes, Paula
author
2016-07-20
A major difficulty in treating alcohol addiction is the high rate of relapse even after
prolonged abstinence. Relapse can be triggered by many factors, including stress, re-exposure to the
drug, conditioned stimuli and exposure to the context in which alcohol consumption occurred. The
opioid receptor antagonist naltrexone has been found to attenuate the adquired behavioral
sensitization to ethanol. The present study investigated the role of naltrexone as an attenuant in
interaction with and specific context in the development of ethanol (2.5 g/kg/day; six sessions)
induced locomotor sensitization in mice. We confirmed the development of behavioral
sensitization to ethanol in two different groups; context and no-context. This was the first step
before the preteatment with naltrexone after the 6 days with treatment of ethanol. Naltrexone (2
mg/kg) was given 30 min before saline or ethanol. Results of these experiments revealed that
administration of a pretreatment (naltrexone) attenuate the induced locomotor sensitization in mice
that were previously being administered ethanol in an specific context but no on those ones that
where in non-specific context. The present data suggest that administration of naltrexone
attenuated the expression of ethanol-induced sensitization, however, this effect was only found with
animals tested in the same context where sensitization developed. These findings are in accordance
with clinical reports claiming the efficacy of naltrexone in the treatment of alcohol relapse in
humans, and indicate that the context may be an useful variable to investigate the biological
mechanisms underlying alcohol relapse.
http://hdl.handle.net/10234/162234
Grau en Psicologia
Grado en Psicología
Bachelor's Degree in Psychology
Ethanol
Behavioral sensitization
Naltrexone
Context
Behavioral sensitization, opioid system and context